Genotoxicity refers to a chemical’s ability to damage genetic material, either directly or indirectly. A genotoxin can cause DNA or chromosomal damage, which can lead to mutations and even cancer. These DNA changes are inheritable between generations of cells.
Genotoxicity testing can detect DNA damage in the form of single and double strand breaks, point mutations, and chromosomal abnormalities. In order for biopharmaceuticals to be registered, researchers must conduct a full assessment of their genotoxic potential. Use of genotox studies decreases the likelihood of late stage failures throughout the drug discovery process. Genotox studies are done both in vitro and in vivo, and are often tested in mammals and rodents.
Since multiple tests are required to ensure a low genetic toxicity, enterprising organizations have been turning abroad in order to minimize the expenses. Specifically, India has a large talent pool of experienced scientists who are able to conduct genotox studies using state-of-the-art equipment. This allows for large savings for Western companies who send this work abroad, since professional labor and technicians are more affordable in India. Indian organizations also have higher capacity, due to large facilities and no shortage of PhD-level researchers to conduct vital parts of the drug discovery process.
With Amritt’s extensive experience working with Indian companies, we can help you select the best-matched supplier to meet your needs and for the scale of your organization.